Professional Summary »
Specializing In »
Practice Locations »
Patient Ratings »
Referring Physicians »
Specializing In
- Fibrous Dysplasia
- Hyperparathyroidism
- Hyperparathyroidism
- Osteogenesis Imperfecta
- Osteoporosis
- Paget's Disease of the Bone
- Vitamin D Deficiency
Biography
Dr Joy Wu is Chief of the Division of Endocrinology and Vice Chair of Basic Science in the Department of Medicine at Stanford. She is a board-certified endocrinologist who specializes in treating osteoporosis and other bone and mineral diseases. She has a special interest in optimizing skeletal health for those at risk of bone loss from glucocorticoid treatment, cancer therapies, or organ transplant. She has served on expert panels and guideline committees for the American Society for Transplantation and Cellular Therapy, the American Society of Clinical Oncology, and the Endocrine Society.
Dr. Wu also directs a basic and translational research program that focuses on skeletal development and the bone marrow hematopoietic niche. Her laboratory is currently studying stem cell therapies for bone formation, and the prevention of cancer metastases to bone (joywulab.stanford.edu). She has been honored with awards from the NIH Director’s New Innovator Award, the Endocrine Society, the American Society for Bone and Mineral Research, and the Mary Kay Foundation, and she is a standing member of the NIH Skeletal Biology Development and Disease study section panel. She has served on the Board of Directors for the Endocrine Society and is currently a member of the governing Council of the American Society for Bone and Mineral Research.
Dr. Wu also directs a basic and translational research program that focuses on skeletal development and the bone marrow hematopoietic niche. Her laboratory is currently studying stem cell therapies for bone formation, and the prevention of cancer metastases to bone (joywulab.stanford.edu). She has been honored with awards from the NIH Director’s New Innovator Award, the Endocrine Society, the American Society for Bone and Mineral Research, and the Mary Kay Foundation, and she is a standing member of the NIH Skeletal Biology Development and Disease study section panel. She has served on the Board of Directors for the Endocrine Society and is currently a member of the governing Council of the American Society for Bone and Mineral Research.
View Full Biography »
Professional Summary
Education & Certifications
- Board Certification: American Board of Internal Medicine, Endocrinology, Diabetes and Metabolism (2006)
- Fellowship: Massachusetts General Hospital (2006) MA
- Residency: Brigham and Women's Hospital Harvard Medical School (2003) MA
- Medical Education: Duke University School of Medicine (2001) NC
- MD/PhD, Duke University (2001)
Honors & Awards
- Alford Distinguished Lecture, Baylor College of Medicine (2019)
- Alpha Omega Alpha, Duke University School of Medicine (1997)
- Cancer Grant Recipient, The Mary Kay Foundation (2013)
- Claflin Distinguished Scholar Award, Massachusetts General Hospital (2009)
- Clinical Scientist Program Instructor Development Award, Harvard Stem Cell Institute (2009)
- Endocrine Scholars Award, The Endocrine Society (2006)
- Faculty Women's Forum Allyship Award, Stanford University (2021)
- Fellow, American Society for Bone and Mineral Research (2021)
- John Haddad Young Investigator Award, Advances in Mineral Metabolism (2008)
- Marsden Memorial Award in Chemistry, Stanford University (1993)
- Merck Senior Fellow Award, The Endocrine Society (2007)
- NIH Director's New Innovator Award, NIH (2011)
- Phi Beta Kappa, Stanford University (1993)
- Young Investigator Award, American Society for Bone and Mineral Research Annual Meeting (2006)
Memberships
- Chair, 2026 Bones and Teeth Gordon Research Conference (2024 - Present)
- Councilor, American Society for Bone and Mineral Research (2022 - Present)
- Member, Scientific Advisory Board, Crinetics Pharmaceuticals (2022 - Present)
- Vice Chair, 2024 Bones and Teeth Gordon Research Conference (2022 - 2024)
- Member, Skeletal Biology Development and Disease Study Section, NIH (2020 - 2024)
- Member, Board of Directors, The Endocrine Society (2019 - 2022)
- Leadership Task Force, The Endocrine Society (2015 - 2015)
- Board of Directors, Advances in Mineral Metabolism (2013 - 2016)
- Membership Enhancement Committee, The American Society for Bone and Mineral Research (2013 - 2016)
- Co-Chair, Trainee & Career Development Core Committee, The Endocrine Society (2007 - 2010)
- Ex Officio, Council, The Endocrine Society (2006 - 2010)
- Member, The American Society for Bone and Mineral Research (2005 - Present)
- Member, The Endocrine Society (2003 - Present)
Administrative Appointments
- Associate Member, Stanford Diabetes Research Center (2018 - Present)
- Chief, Division of Endocrinology, Gerontology and Metabolism (2022 - Present)
- Co-Director, Translational Investigator Program, Department of Medicine (2015 - 2022)
- Steering Committee Member, Team Science Initiative, Department of Medicine (2022 - Present)
- Vice Chair, Basic and Translational Science, Department of Medicine (2020 - Present)
Publications
-
Ca2+/calmodulin-dependent protein kinase IV is expressed in spermatids and targeted to chromatin and the nuclear matrix
Wu, J. Y., & Means, A. R. (2000). Ca2+/calmodulin-dependent protein kinase IV is expressed in spermatids and targeted to chromatin and the nuclear matrix. JOURNAL OF BIOLOGICAL CHEMISTRY, 275(11), 7994–7999. -
Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4
Wu, J. Y., Ribar, T. J., Cummings, D. E., Burton, K. A., McKnight, G. S., & Means, A. R. (2000). Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4. NATURE GENETICS, 25(4), 448–452. -
Female fertility is reduced in mice lacking Ca2+ calmodulin-dependent protein kinase IV
Wu, J. Y., Gonzalez-Robayna, I. J., Richards, J. S., & Means, A. R. (2000). Female fertility is reduced in mice lacking Ca2+ calmodulin-dependent protein kinase IV. ENDOCRINOLOGY, 141(12), 4777–4783. -
Spermatogenesis and the regulation of Ca2+-calmodulin-dependent protein kinase IV localization are not dependent on calspermin
Wu, J. Y., Ribar, T. J., & Means, A. R. (2001). Spermatogenesis and the regulation of Ca2+-calmodulin-dependent protein kinase IV localization are not dependent on calspermin. MOLECULAR AND CELLULAR BIOLOGY, 21(17), 6066–6070. -
Osteoblastic regulation of B lymphopoiesis is mediated by G(s)alpha-dependent signaling pathways
Wu, J. Y., Purton, L. E., Rodda, S. J., Chen, M., Weinstein, L. S., McMahon, A. P., … Kronenberg, H. M. (2008). Osteoblastic regulation of B lymphopoiesis is mediated by G(s)alpha-dependent signaling pathways. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(44), 16976–16981. -
Role of the Osteoblast Lineage in the Bone Marrow Hematopoietic Niches
Wu, J. Y., Scadden, D. T., & Kronenberg, H. M. (2009). Role of the Osteoblast Lineage in the Bone Marrow Hematopoietic Niches. JOURNAL OF BONE AND MINERAL RESEARCH, 24(5), 759–764. -
Potent constitutive cyclic AMP-generating activity of XL alpha s implicates this imprinted GNAS product in the pathogenesis of McCune-Albright Syndrome and fibrous dysplasia of bone
Mariot, V., Wu, J. Y., Aydin, C., Mantovani, G., Mahon, M. J., Linglart, A., & Bastepe, M. (2011). Potent constitutive cyclic AMP-generating activity of XL alpha s implicates this imprinted GNAS product in the pathogenesis of McCune-Albright Syndrome and fibrous dysplasia of bone. BONE, 48(2), 312–320. -
G(s)alpha enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice
Wu, J. Y., Aarnisalo, P., Bastepe, M., Sinha, P., Fulzele, K., Selig, M. K., … Kronenberg, H. M. (2011). G(s)alpha enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice. JOURNAL OF CLINICAL INVESTIGATION, 121(9), 3492–3504. -
Myelopoiesis is regulated by osteocytes through Gsa-dependent signaling.
Fulzele, K., Krause, D. S., Panaroni, C., Saini, V., Barry, K. J., Liu, X., … Divieti Pajevic, P. (2013). Myelopoiesis is regulated by osteocytes through Gsa-dependent signaling. Blood, 121(6), 930–939. -
Interactions between B lymphocytes and the osteoblast lineage in bone marrow.
Panaroni, C., & Wu, J. Y. (2013). Interactions between B lymphocytes and the osteoblast lineage in bone marrow. Calcified Tissue International, 93(3), 261–68. -
Differential regulation of myeloid leukemias by the bone marrow microenvironment.
Krause, D. S., Fulzele, K., Catic, A., Sun, C. C., Dombkowski, D., Hurley, M. P., … Scadden, D. T. (2013). Differential regulation of myeloid leukemias by the bone marrow microenvironment. Nature Medicine, 19(11), 1513–1517. -
Teriparatide ( PTH1-34) Treatment Increases Peripheral Hematopoietic Stem Cells in Postmenopausal Women
Yu, E. W., Kumbhani, R., Siwila-Sackman, E., DeLelys, M., Preffer, F. I., Leder, B. Z., & Wu, J. Y. (2014). Teriparatide ( PTH1-34) Treatment Increases Peripheral Hematopoietic Stem Cells in Postmenopausal Women. JOURNAL OF BONE AND MINERAL RESEARCH, 29(6), 1380–86. -
Mesenchymal progenitors and the osteoblast lineage in bone marrow hematopoietic niches.
Panaroni, C., Tzeng, Y.-S., Saeed, H., & Wu, J. Y. (2014). Mesenchymal progenitors and the osteoblast lineage in bone marrow hematopoietic niches. Current Osteoporosis Reports, 12(1), 22–32. -
The PTH-G alpha(s)-Protein Kinase A Cascade Controls alpha NAC Localization To Regulate Bone Mass
Pellicelli, M., Miller, J. A., Arabian, A., Gauthier, C., Akhouayri, O., Wu, J. Y., … St-Arnaud, R. (2014). The PTH-G alpha(s)-Protein Kinase A Cascade Controls alpha NAC Localization To Regulate Bone Mass. MOLECULAR AND CELLULAR BIOLOGY, 34(9), 1622–33. -
Development of the skeleton
Provot, S., Schipani, E., Wu, J. Y., & Kronenberg, H. M. (2013). Development of the skeleton. Osteoporosis, 4th Edition (pp. 97–126). Academic Press. -
The role of bone cells in establishing the hematopoietic stem cell niche
Wu, J. Y., & Kronenberg, H. M. (2011). The role of bone cells in establishing the hematopoietic stem cell niche. Osteoimmunology: Interactions of the Immune and Skeletal Systems (pp. 81–99). -
Wnts produced by Osterix-expressing osteolineage cells regulate their proliferation and differentiation.
Tan, S. H., Senarath-Yapa, K., Chung, M. T., Longaker, M. T., Wu, J. Y., & Nusse, R. (2014). Wnts produced by Osterix-expressing osteolineage cells regulate their proliferation and differentiation. Proceedings of the National Academy of Sciences of the United States of America, 111(49), E5262–71. -
Activation of the Wnt/Planar Cell Polarity Pathway Is Required for Pericyte Recruitment during Pulmonary Angiogenesis.
Yuan, K., Orcholski, M. E., Panaroni, C., Shuffle, E. M., Huang, N. F., Jiang, X., … de Jesus Perez, V. A. (2015). Activation of the Wnt/Planar Cell Polarity Pathway Is Required for Pericyte Recruitment during Pulmonary Angiogenesis. American Journal of Pathology, 185(1), 69–84. -
Loss of G(s)alpha Early in the Osteoblast Lineage Favors Adipogenic Differentiation of Mesenchymal Progenitors and Committed Osteoblast Precursors
Sinha, P., Aarnisalo, P., Chubb, R., Ono, N., Fulzele, K., Selig, M., … Wu, J. Y. (2014). Loss of G(s)alpha Early in the Osteoblast Lineage Favors Adipogenic Differentiation of Mesenchymal Progenitors and Committed Osteoblast Precursors. JOURNAL OF BONE AND MINERAL RESEARCH, 29(11), 2414–26. -
Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow.
Yu, V. W., Saez, B., Cook, C., Lotinun, S., Pardo-Saganta, A., Wang, Y.-H. H., … Scadden, D. T. (2015). Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow. The Journal of Experimental Medicine. -
PTH Signaling in Osteoprogenitors Is Essential for B-Lymphocyte Differentiation and Mobilization.
Panaroni, C., Fulzele, K., Saini, V., Chubb, R., Pajevic, P. D., & Wu, J. Y. (2015). PTH Signaling in Osteoprogenitors Is Essential for B-Lymphocyte Differentiation and Mobilization. Journal of Bone and Mineral Research , 30(12), 2273–86. -
RAR gamma is a negative regulator of osteoclastogenesis
Green, A. C., Poulton, I. J., Vrahnas, C., Haeusler, K. D., Walkley, C. R., Wu, J. Y., … Purton, L. E. (2015). RAR gamma is a negative regulator of osteoclastogenesis. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 150, 46–53. -
Pluripotent Stem Cells and Skeletal Regeneration-Promise and Potential
Wu, J. Y. (2015). Pluripotent Stem Cells and Skeletal Regeneration-Promise and Potential. CURRENT OSTEOPOROSIS REPORTS, 13(5), 342–50. -
Loss of Gsa in the Postnatal Skeleton Leads to Low Bone Mass and a Blunted Response to Anabolic Parathyroid Hormone Therapy.
Sinha, P., Aarnisalo, P., Chubb, R., Poulton, I. J., Guo, J., Nachtrab, G., … Wu, J. Y. (2016). Loss of Gsa in the Postnatal Skeleton Leads to Low Bone Mass and a Blunted Response to Anabolic Parathyroid Hormone Therapy. Journal of Biological Chemistry, 291(4), 1631–42. -
Calcinosis is associated with digital ulcers and osteoporosis in patients with systemic sclerosis: A Scleroderma Clinical Trials Consortium study
Valenzuela, A., Baron, M., Herrick, A. L., Proudman, S., Stevens, W., Rodriguez-Reyna, T. S., … Chung, L. (2016). Calcinosis is associated with digital ulcers and osteoporosis in patients with systemic sclerosis: A Scleroderma Clinical Trials Consortium study. SEMINARS IN ARTHRITIS AND RHEUMATISM, 46(3), 344–49. -
Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the, bone marrow
Johnson, R. W., Fingers, E. C., Olcina, M. M., Vilalta, M., Aguilera, T., Miao, Y., … Giaccia, A. J. (2016). Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the, bone marrow. NATURE CELL BIOLOGY, 18(10), 1078–89. -
SIKs control osteocyte responses to parathyroid hormone
Wein, M. N., Liang, Y., Goransson, O., Sundberg, T. B., Wang, J., Williams, E. A., … Kronenberg, H. M. (2016). SIKs control osteocyte responses to parathyroid hormone. NATURE COMMUNICATIONS, 7. -
Evidence for use of Teriparatide in Spinal Fusion Surgery in Osteoporotic Patients.
Chaudhary, N., Lee, J. S., Wu, J. Y., & Tharin, S. (2016). Evidence for use of Teriparatide in Spinal Fusion Surgery in Osteoporotic Patients. World Neurosurgery. -
Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate.
Fan, Y., Hanai, J.-ichi, Le, P. T., Bi, R., Maridas, D., DeMambro, V., … Lanske, B. (2017). Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate. Cell Metabolism. -
Older Men with Anemia Have Increased Fracture Risk Independent of Bone Mineral Density.
Valderrábano, R. J., Lee, J., Lui, L.-Y., Hoffman, A. R., Cummings, S. R., Orwoll, E. S., & Wu, J. Y. (2017). Older Men with Anemia Have Increased Fracture Risk Independent of Bone Mineral Density. Journal of Clinical Endocrinology and Metabolism. -
Foxp3(+) regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis
Pierini, A., Nishikii, H., Baker, J., Kimura, T., Kwon, H.-S., Pan, Y., … Negrin, R. S. (2017). Foxp3(+) regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis. NATURE COMMUNICATIONS, 8. -
Gs alpha Controls Cortical Bone Quality by Regulating Osteoclast Differentiation via cAMP/PKA and beta-Catenin Pathways
Ramaswamy, G., Kim, H., Zhang, D., Lounev, V., Wu, J. Y., Choi, Y., … Shore, E. M. (2017). Gs alpha Controls Cortical Bone Quality by Regulating Osteoclast Differentiation via cAMP/PKA and beta-Catenin Pathways. SCIENTIFIC REPORTS, 7. -
Development of the Skeleton
Provot, S., Schipani, E., Wu, J. Y., & Kronenberg, H. M. (2008). Development of the Skeleton. Osteoporosis, 3rd Edition (pp. 241–269). Academic Press. -
Bone Density Loss Is Associated With Blood Cell Counts
Valderrabano, R. J., Lui, L.-Y., Lee, J., Cummings, S. R., Orwoll, E. S., Hoffman, A. R., & Wu, J. Y. (2017). Bone Density Loss Is Associated With Blood Cell Counts. JOURNAL OF BONE AND MINERAL RESEARCH, 32(2), 212–20. -
Pharmacology
Wu, J. Y. (1999). Pharmacology. Crashing the boards: a user friendly study guide for the USMLE step 1 (pp. 31–47). Lippincott Williams and Wilkins. -
Clarifying the contributions of distinct mesenchymal populations in supporting hematopoiesis [editorial]
Wu, J. Y. (2010). Clarifying the contributions of distinct mesenchymal populations in supporting hematopoiesis [editorial]. IBMS BoneKEy , 7. -
In vivo rescue of the hematopoietic niche by pluripotent stem cell complementation of defective osteoblast compartments.
Chubb, R., Oh, J., Riley, A. K., Kimura, T., Wu, S. M., & Wu, J. Y. (2017). In vivo rescue of the hematopoietic niche by pluripotent stem cell complementation of defective osteoblast compartments. Stem Cells (Dayton, Ohio). -
Prevention of breast cancer skeletal metastases with parathyroid hormone.
Swami, S., Johnson, J., Bettinson, L. A., Kimura, T., Zhu, H., Albertelli, M. A., … Wu, J. Y. (2017). Prevention of breast cancer skeletal metastases with parathyroid hormone. JCI Insight, 2(17). -
Constitutive stimulatory G protein activity in limb mesenchyme impairs bone growth.
Karaca, A., Malladi, V. R., Zhu, Y., Tafaj, O., Paltrinieri, E., Wu, J. Y., … Bastepe, M. (2018). Constitutive stimulatory G protein activity in limb mesenchyme impairs bone growth. Bone, 110, 230–37. -
Bone and blood interactions in human health and disease.
Valderrábano, R. J., & Wu, J. Y. (2018). Bone and blood interactions in human health and disease. Bone. -
Bone Marrow Hematopoietic Niches
Wu, J. Y., & Kronenberg, H. M. (2016). Bone Marrow Hematopoietic Niches. OSTEOIMMUNOLOGY: INTERACTIONS OF THE IMMUNE AND SKELETAL SYSTEMS, 2ND EDITION, 103–19. -
Preconditioned or IL4-Secreting Mesenchymal Stem Cells Enhanced Osteogenesis at Different Stages
Lin, T., Kohno, Y., Huang, J.-F., Romero-Lopez, M., Maruyama, M., Ueno, M., … Goodman, S. B. (2019). Preconditioned or IL4-Secreting Mesenchymal Stem Cells Enhanced Osteogenesis at Different Stages. TISSUE ENGINEERING PART A. -
Association of bone mineral density with hemoglobin and change in hemoglobin among older men and women: The Cardiovascular Health Study
Valderrabano, R. J., Buzkova, P., Chang, P.-Y., Zakai, N. A., Fink, H. A., Robbins, J. A., … Wu, J. Y. (2019). Association of bone mineral density with hemoglobin and change in hemoglobin among older men and women: The Cardiovascular Health Study. BONE, 120, 321–26. -
Mesenchymal lineage cells and their importance in B lymphocyte niches
Green, A. C., Rudolph-Stringer, V., Chantry, A. D., Wu, J. Y., & Purton, L. E. (2019). Mesenchymal lineage cells and their importance in B lymphocyte niches. BONE, 119, 42–56. -
Pluripotent stem cells as a source of osteoblasts for bone tissue regeneration
Zhu, H., Kimura, T., Swami, S., & Wu, J. Y. (2019). Pluripotent stem cells as a source of osteoblasts for bone tissue regeneration. BIOMATERIALS, 196, 31–45. -
Direct reprogramming of mouse fibroblasts into functional osteoblasts.
Zhu, H., Swami, S., Yang, P., Shapiro, F., & Wu, J. (2019). Direct reprogramming of mouse fibroblasts into functional osteoblasts. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. -
Woven bone overview: structural classification based on its integral role in developmental, repair and pathological bone formation throughout vertebrate groups.
Shapiro, F., & Wu, J. Y. (2019). Woven bone overview: structural classification based on its integral role in developmental, repair and pathological bone formation throughout vertebrate groups. European Cells & Materials, 38, 137–167. -
Increased NF-kappa B Activity in Osteoprogenitor-Lineage Cells Impairs the Balance of Bone Versus Fat in the Marrow of Skeletally Mature Mice
Lin, T., Pajarinen, J., Kohno, Y., Nabeshima, A., Lu, L., Nathan, K., … Goodman, S. (2020). Increased NF-kappa B Activity in Osteoprogenitor-Lineage Cells Impairs the Balance of Bone Versus Fat in the Marrow of Skeletally Mature Mice. REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE, 6(1), 69–77. -
Induction of Osteoblasts by Direct Reprogramming of Mouse Fibroblasts.
Zhu, H., & Wu, J. Y. (2020). Induction of Osteoblasts by Direct Reprogramming of Mouse Fibroblasts. Methods in Molecular Biology (Clifton, N.J.), 2155, 201–12. -
Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes.
Buikema, J. W., Lee, S., Goodyer, W. R., Maas, R. G., Chirikian, O., Li, G., … Wu, S. M. (2020). Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes. Cell Stem Cell, 27(1), 50–63.e5. -
Bone Health Management After Hematopoietic Cell Transplantation: An Expert Panel Opinion from the American Society for Transplantation and Cellular Therapy.
Bar, M., Ott, S. M., Lewiecki, E. M., Sarafoglou, K., Wu, J. Y., Thompson, M. J., … Carpenter, P. A. (2020). Bone Health Management After Hematopoietic Cell Transplantation: An Expert Panel Opinion from the American Society for Transplantation and Cellular Therapy. Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. -
Calcinosis is associated with ischemic manifestations and increased disability in patients with systemic sclerosis.
Valenzuela, A., Baron, M., Rodriguez-Reyna, T. S., Proudman, S., Khanna, D., Young, A., … Chung, L. (2020). Calcinosis is associated with ischemic manifestations and increased disability in patients with systemic sclerosis. Seminars in Arthritis and Rheumatism, 50(5), 891–96. -
Histopathology of osteogenesis imperfecta bone. Supramolecular assessment of cells and matrices in the context of woven and lamellar bone formation using light, polarization and ultrastructural microscopy.
Shapiro, F., Maguire, K., Swami, S., Zhu, H., Flynn, E., Wang, J., & Wu, J. Y. (2021). Histopathology of osteogenesis imperfecta bone. Supramolecular assessment of cells and matrices in the context of woven and lamellar bone formation using light, polarization and ultrastructural microscopy. Bone Reports, 14, 100734. -
The characterization of distinct populations of murine skeletal cells that have different roles in B lymphopoiesis.
Green, A. C., Tjin, G., Lee, S. C., Chalk, A. M., Straszkowski, L., Kwang, D., … Purton, L. E. (2021). The characterization of distinct populations of murine skeletal cells that have different roles in B lymphopoiesis. Blood. -
Finding My Voice.
Wu, J. Y. (2021). Finding My Voice. Annals of Internal Medicine. -
Considering Race and Ethnicity in the Management of Bone Health.
Wu, J. Y. (2021). Considering Race and Ethnicity in the Management of Bone Health. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. -
Sex Differences in Mesenchymal Stem Cell Therapy With Gelatin-Based Microribbon Hydrogels in a Murine Long Bone Critical-Size Defect Model.
Ueno, M., Zhang, N., Hirata, H., Barati, D., Utsunomiya, T., Shen, H., … Goodman, S. B. (2021). Sex Differences in Mesenchymal Stem Cell Therapy With Gelatin-Based Microribbon Hydrogels in a Murine Long Bone Critical-Size Defect Model. Frontiers in Bioengineering and Biotechnology, 9, 755964. -
Use of Adjuvant Bisphosphonates and Other Bone-Modifying Agents in Breast Cancer: ASCO-OH (CCO) Guideline Update.
Eisen, A., Somerfield, M. R., Accordino, M. K., Blanchette, P. S., Clemons, M. J., Dhesy-Thind, S., … Van Poznak, C. H. (2022). Use of Adjuvant Bisphosphonates and Other Bone-Modifying Agents in Breast Cancer: ASCO-OH (CCO) Guideline Update. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, JCO2102647. -
Pandemic-related barriers to the success of women in research: a framework for action.
Davis, P. B., Meagher, E. A., Pomeroy, C., Lowe, W. L., Rubenstein, A. H., Wu, J. Y., … Jackson, R. D. (2022). Pandemic-related barriers to the success of women in research: a framework for action. Nature Medicine. -
Ageing attenuates bone healing by mesenchymal stem cellsin a microribbon hydrogelwith a murine long bone critical-size defect model.
Hirata, H., Zhang, N., Ueno, M., Barati, D., Kushioka, J., Shen, H., … Goodman, S. B. (2022). Ageing attenuates bone healing by mesenchymal stem cellsin a microribbon hydrogelwith a murine long bone critical-size defect model. Immunity & Ageing : I & A, 19(1), 14. -
Loss of parathyroid hormone receptor signaling in osteoprogenitors is associated with accumulation of multiple hematopoietic lineages in the bone marrow.
Kimura, T., Panaroni, C., Rankin, E. B., Purton, L. E., & Wu, J. Y. (2022). Loss of parathyroid hormone receptor signaling in osteoprogenitors is associated with accumulation of multiple hematopoietic lineages in the bone marrow. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. -
Development of the Skeleton
Provot, S., Schipani, E., Wu, J. Y., & Kronenberg, H. M. (2021). Development of the Skeleton. Osteoporosis, 5th Edition (pp. 39–73). Academic Press. -
Pandemic magnifies gender inequities, provides opportunities for long-range solutions in academic medicine
Wu, J. Y. (2021). Pandemic magnifies gender inequities, provides opportunities for long-range solutions in academic medicine. Stanford Clayman Institute for Gender Research. Retrieved from https://gender.stanford.edu/news-publications/gender-news/pandemic-magnifies-gender-inequities-provides-opportunities-long-range -
Twitter takes off at #ENDO2018
Wu, J. Y. (2018). Twitter takes off at #ENDO2018. Op-(m)ed Doximity. Retrieved from https://opmed.doximity.com/twitter-takes-off-at-endo2018-5d37b6af777a -
Newly Approved Osteoporosis Drug Is 'Promising' and 'Welcome'
Wu, J. Y. (2019). Newly Approved Osteoporosis Drug Is 'Promising' and 'Welcome'. Medscape. Retrieved from https://www.medscape.com/viewarticle/911616 -
Twitter and the Endocrinologist’s Response to COVID-19
Wu, J. Y. (2020). Twitter and the Endocrinologist’s Response to COVID-19. Endocrine News. Retrieved from https://endocrinenews.endocrine.org/twitter-and-the-endocrinologists-response-to-covid-19/ -
Pandemic Challenges and Opportunities for Gender Equity in Clinical Research
Wu, J. Y., & Davis, P. B. (2022). Pandemic Challenges and Opportunities for Gender Equity in Clinical Research. Applied Clinical Trials, 31. -
How can we achieve gender equity in endocrinology?
Wu, J. Y. (2022). How can we achieve gender equity in endocrinology? Endocrine Views, 48. -
Osteoblast Lineage Support of Hematopoiesis in Health and Disease.
Kim, M. J., Valderrabano, R. J., & Wu, J. Y. (2022). Osteoblast Lineage Support of Hematopoiesis in Health and Disease. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. -
Sex-Specific Differences in Gsa-Mediated Signaling Downstream of PTH1R Activation by Abaloparatide in Bone.
Swami, S., Johnson, J., Vecchi, L. A., Kim, M. J., Lanske, B., Johnson, R. W., & Wu, J. Y. (2022). Sex-Specific Differences in Gsa-Mediated Signaling Downstream of PTH1R Activation by Abaloparatide in Bone. JBMR Plus, 6(12), e10695. -
Treatment of Hypercalcemia of Malignancy in Adults: An Endocrine Society Clinical Practice Guideline.
Fuleihan, G. E.-H., Clines, G. A., Hu, M. I., Marcocci, C., Murad, M. H., Piggott, T., … Drake, M. T. (2022). Treatment of Hypercalcemia of Malignancy in Adults: An Endocrine Society Clinical Practice Guideline. The Journal of Clinical Endocrinology and Metabolism. -
Parathyroid hormone receptor (PTH1R) signaling mediates breast cancer metastasis to bone in mice.
Swami, S., Zhu, H., Nisco, A., Kimura, T., Kim, M. J., Nair, V., & Wu, J. Y. (2023). Parathyroid hormone receptor (PTH1R) signaling mediates breast cancer metastasis to bone in mice. JCI Insight. -
Spatially patterned 3D model mimics key features of cancer metastasis to bone.
González Díaz, E. C., Tai, M., Monette, C. E., Wu, J. Y., & Yang, F. (2023). Spatially patterned 3D model mimics key features of cancer metastasis to bone. Biomaterials, 299, 122163. -
The role of vesicle trafficking genes in osteoblast differentiation and function.
Zhu, H., Su, Y., Wang, J., & Wu, J. Y. (2023). The role of vesicle trafficking genes in osteoblast differentiation and function. Scientific Reports, 13(1), 16079. -
Pudgy mouse rib deformities emanate from abnormal paravertebral longitudinal cartilage/bone accumulations.
Shapiro, F., Wang, J., Flynn, E., & Wu, J. Y. (2024). Pudgy mouse rib deformities emanate from abnormal paravertebral longitudinal cartilage/bone accumulations. Biology Open, 13(1).
Clinical Trials
Clinical trials are research studies that evaluate a new medical approach, device, drug, or other treatment. As a Stanford Health Care patient, you may have access to the latest, advanced clinical trials.
Open trials refer to studies currently accepting participants. Closed trials are not currently enrolling, but may open in the future.
Practice Locations
Osteoporosis and Metabolic Bone Diseases Clinic Stanford, CA
Stanford, CA
Osteoporosis and Metabolic Bone Diseases Clinic
300 Pasteur Drive , 1st Floor, Suite A175
Stanford , CA 94305
Make An Appointment More Clinic Information » Getting Here »Diabetes Care Program Palo Alto, CA
Palo Alto, CA
Diabetes Care Program
211 Quarry Road
Palo Alto , CA 94304
Make An Appointment More Clinic Information » Getting Here »Endocrinology Clinic at Hoover Pavilion Palo Alto, CA
Palo Alto, CA
Endocrinology Clinic at Hoover Pavilion
211 Quarry Road, 2nd Floor, Suite 205
Palo Alto , CA 94304
Make An Appointment More Clinic Information » Getting Here »Important Information about Our Organizations and Physician Affiliation
Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are each independent nonprofit organizations that are affiliated with but separate from each other and from Stanford University. The physicians who provide care at facilities operated by Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners are faculty, foundation, or community physicians who are not employees, representatives, or agents of Stanford Health Care, Stanford Health Care Tri- Valley, or Stanford Medicine Partners. Stanford Health Care, Stanford Health Care Tri-Valley, and Stanford Medicine Partners do not exercise control over the care provided by such faculty, foundation, and community physicians and are not responsible for their actions.
Patient Reviews
(136 reviews)
I so appreciate Dr. Wu. She is always prepared for our visit; she reviews my history thoroughly before the appointment. She responds to all of my questions and addresses all of my concerns. I leave the visit with a clear understanding of next steps and what to expect.
Excellent physician!
She is very knowledgeable and has very good social skills.
Dr. Wu is attentive and has handled my case with highest aplomb. It is a pleasure to partner with her on my care. I appreciate her careful and complete answer to my questions and knowledge of my unusual case.
Excellent service. Always takes her patient's health into consideration. Thank you for the awesome service and allowing us to do it thru video/computer.
Very helpful visit that really made me comfortable about my care and allayed all my concerns
She is extremely knowledgeable and shows a lot of concern and empathy
She is very professional, competent, knowledgeable and semi o be a caring and nice person.
We began out visits during Covid.
Excellent specialist—knowledgeable, kind, and efficient! I wish all doctors were just like her!
It’s always pleasant to have a visit with Dr. Joy by video or in person.
She came on promptly for the appointment. She is very professional and confident about her field of work.
Dr. Wu is an excellent doctor. I've seen her in person and over video visits for 8-10 years now, and I'm very pleased with her care. She knows a great deal about my particular issue, bone health, and I trust her advice. She takes the time to answer my questions, and has a positive approach to dealing with me as a patient. I feel lucky to have her as part of my healthcare team. Very pleased with her.
Dr. Wu is warm, gracious, personable, and caring, on top of having an excellent expertise in her field. I trust Dr. Wu and that trust goes a long way to help facilitate and extend the success of treatments. I have no doubt that Dr. Wu has paid a great attention to my health history and condition and has my best interest in her consideration.
It's always a JOY to work with Dr. Joy Wu. Thank you for your special care.
Dr. Wu is an outstanding provider. She listens, she explains, she is very attentive and focused on her patient. She is very knowledgeable and answers all questions completely and with respect.
Excellent physician. Clearly cares about her patients wellness. Answers questions. Includes patient in decision making.
She is very pleasant and patiently answers any questions we might have.
Dr. Wu is an excellent practitioner. I highly recommend her for her high quality skills and attention to detail. Her bedside manner is outstanding.
Super professional. I'm in very good hands.
Outstanding Physician!
She is very knowledgeable and professional.
Dr. Wu's expertise is greatly appreciated. We need more physicians like her!
Dr. Wu is the best!
A perfect visit
Excellent top to bottom
Understands my feelings, helpful resource, caring
Warm, friendly, knowledgeable
Doctor and staff were professional and respectful and listened to my issues. Office was clean and sanitary
Dr Wu and her assistant were excellent. I so appreciated that they had looked at my records before my appointment
She is a wonderful doctor—so smart, articulate, sensitive, and kind. She has helped me so much, and I am grateful.
Dr. Wu is approachable, knowledgeable and explains things in a clear and understandable way.way
Everyone is always helpful and caring
I was very happy she made time to see me at last minute call . I had some family problems and she was great accommodating me.
She’s excellent
I really enjoy having Dr. Wu as my doctor. She is up to date regarding my information and up to date regarding what is best practice for my osteoporosis. She is very compassionate and enjoyable to talk to.
Dr. Wu takes amazing care of me! I am very confident in her care!
Dr. Joy Wu listened to my concerns and explained options available to me.
Super friendly and knowledgeable.
Dr. Wu is one of my favorite care providers. She is always engaging, communicative, and interested as me as an individual. I look forward to our annual visit.
Dr Wu offered was incredibly knowledgeable. I came with a many questions and information from studies I had read. She sorted through that and offered answers as to how that applied to me. Offered new perspective and a plan. Very informative and I felt part of the “team.â€
excellent doctor
Dr Wu always makes sure she has answered all my questions. She never seems hurried and is willing to discuss treatment options
Friendly and helpful
Super doctor!
great md
Dr Wu is very knowledgeable and professional. She is the best doctor I have ever had.
Very helpful, also her assistant. Always great to work with!
Dr Joy Wu is a fabulous doctor! I never feel rushed. She always makes sure we have addressed all my concerns. Very professional and personable. I am grateful to have her as one of Stanford doctors!
Concise, without missing information.
Appreciated the time to visit about my concerns.
Joy and the other doctors are excellent!
Excellent doctor and great visit. Thank you.
Excellent physician!
I had a through exam of my lungs, and limbs by the resident, and then had a discussion with Dr. Wu. I am very pleased with the care and service that I received. I will recommend Dr. Wu.
Dr. Wu and Dr. Hughes were excellent and took time to listen, asses and answer all of my questions. I didn’t feel rushed and felt my concerns were taken seriously.
I especially appreciate suggestions of alternative medication regiment which will make managing them less onerous for me.
I also appreciated Dr. Wu taking the time to explain her research and how it relates to my condition.
Excellent team from front office staff to nurses to Doctors!
Dr. Wu is an excellent physician. She is exceptionally knowledgeable and communicates very well. She reviewed Joan's medical status and gave very clear instructions about her care. She responded clearly and completely to the questions Joan asked. Because of Dr. Wu, we have a clear understanding of Joan's state of health, the medication she needs to take, the blood test she needs, and what we may expect in the future.
We love and respect Dr Wu, she is a very good Doctor. Thank you, Dr. Wu.
fantastic doctor and person
Very personable. Didn’t just call about my health; remembered I was getting married and asked about that. She made me feel liked she not only cared about my physical health but my personal well being also Very pleasant and answered all of my questions!!!
Dr. Wu is phenomenal. She is kind and patient, listens closely, and is genuine in her interactions.
Dr. Wu is brilliant, empathetic, a careful listener and a fabulous doctor. I feel so lucky to have her guiding my care. She explains everything to me in 'lay' language, is current with the latest research, and asks me about any questions I may have. She is always on time, professional, and caring.
I have complete confidence in Dr. Wu, and I would highly recommend her.
She is very caring and thoughtful
Thank you!
Wonderful doctor! So knowledgeable, efficient, and compassionate!
Enjoy talking to her she made me feel very comfortable
She is an extremely good doctor!!!!!
Dr. Wu has always been thoughtful and thorough. I appreciate her care!
Dr. Wu was pleasant, as always.
She was able to answer all of my concerns re: side-effects of my
Reclast infusion.
She was knowledgeable about latest information about taking too much
vitamin D.
She explained why I only have a Bone Density every 2 years.
I feel relaxed and informed after meeting with Dr. Wu today.
Very patient. Thank you.
Dr. Wu is a great asset to Stanford hospital.
Great doctor. I really like her.
Excellent physician
She was wonderful, able to think across fields, able to grasp all that I have been struggling with doctors to grasp for more than six months. I am intensely relieved to have the consultation and hear her perspective and I needed her expertise in bone health from an Endocrinology perspective.
She can be more courteous and friendly. She was years ago when in person, but not time in tele visit.
DR, wu answers all questions. Gives practical advise and the reasons for the specific course of action. I feel that I am in good hands.
Dr. Wu is everything you'd want in a physician. She asks pertinent questions, follows up when requests are made, and even remembers non-treatment related facts about her patients. It's always a pleasure to see her. She never seems rushed or in a hurry to get on to the next person - you feel like she's really in the moment with you and not looking ahead on the day's calendar.
In short, she's great!
Dr. Wu was friendly, attentive to my needs and understood my complicated health scenario.
Very smart, informed, and pleasant to deal with. I like her a lot! She has a good plan, well articulated.
Dr. Wu and her team are excellent physicians
Dr. Wu is an excellent care provider. She’s thoughtful, thorough and explains things in a very understandable manner.
Excellent visit.
She’s wonderful!
Dr. Wu is a caring and compassionate professional. She answers all my questions in a direct and unhurried manner. I feel fortunate to have her as my endocrinologist.
Joy Wu is extremely knowledgable and caring practitioner. She is an awesome specialist and great doctor!
Very informative. Gave me a lot of good information about medications.
Excellent doctor who came in prepared, showed understanding & empathy. She also replied online questions promptly.
Could not have been better.
Excellent provider.
I have the utmost confidence in Dr. Joy Wu's knowledge of her practice and appreciate her candidness & the time she spends with me as her client.
Dr. Wu is terrific!
Dr. Wu is an awesome doctor. She is thorough and very interested in my concerns.
Dr. Wu was extremely thorough & gave me ample time!
Dr. Wu has a deep understanding of my condition and treatment strategies and options. I trust her decisions completely. She is articulate, explains the plan, interacts with me, and simply provides outstanding care.
Dr. Wu is GREAT! She's pleasant, patient, knowledgeable and takes the time to explain things to us.
Dr. Wu was excellent very caring & fantastic bedside manner.
My experience was very good. Doctor & resident were very clear in their explanations & answers to my questions. Treated me with kindness and spent time with me. I had not received that respectful/caring treatment with my personal GP doctor. So I am very happy at Stanford.
Thank you Dr. Wu for your professional and loving care.
Doctor is very knowledgeable and supportive.
Dr. Wu is an incredibly caring and thorough doctor. I highly recommend her.
She seemed very competent & answered all my questions.
Dr. Wu does a great job of understanding all my concerns and explaining all my options. I feel like we are partners in my care.
Doctor Wu was wonderful - explained very thoroughly - where I was able to understand. Very warm.
So glad I came!! So grateful I got a second opinion!!
Re: words I could understand - Dr. Wu used alternative words when I showed I did not understand. She is great.
This consultation with Dr. Wu was very helpful in helping me weigh all the pros & cons of taking Prolia I had lots of questions and she took the time to give me very detailed and personalized explanations taking into account my own physical condition. Very helpful!
Dr. Wu is exceptionally knowledgeable and devoted the time needed to go over the plan and to answer all of my questions in detail.
Dr. Wu is awesome!
Dr. Wu is a very very good doctor. I would recommend her to anybody who needs the care! Thank you! Dr. Wu, you are the best!!!
Dr. Joy Wu is the best doctor/specialist I have ever worked with, and I have very high confidence in my treatment by her.
Dr. Wu is by far the BEST DOCTOR I've EVER had. She listens & completely included me in her decisions. She took my specific needs into account & discussed w/me her plan & reasoning. Absolutely awesome!!
I really liked Dr. Wu, she spent a lot of time with me - explained test results & implications for short & long term future. She was empathetic & thorough.
Dr. Wu is great & I loved how she walked me through a mathematical analysis of my risk factors.
Dr. Joy Wu is an exceptional physician. Truly concerned for my welfare. Includes me in all discussions and plan of care. Takes care of me as a total person -> physical, mental, emotional. She is the best and a great researcher!
Can't say enough good things about care provider. Please thank Dr. Wu.
I was favorably impressed with Dr. Joy Wu & knowledge of my condition and confident of her recommendations.
Excellent experience.
Dr. Wu is outstanding...quite simply the best endocrinologist I've consulted ever.
Dr. Wu was wonderful - professional and friendly.
Very good experience with Dr. Wu and all others in the clinic.
Excellent doctor.
My experience with Dr. Joy Wu continues to be excellent. She is genuinely concerned for me as her patient - my well being and includes me in her plan of care! After giving her professional best recommendation, the time plan is decided by MD and patient together. She is exceptional.
Very good experience, thanks very much, Dr. Wu!
Dr. Wu is excellent!!
Dr. Wu was very easy to talk to. She discussed my condition and the plan to treat thoroughly and made sure all of my questions were answered.
Dr. Wu is a very patient - friendly MD. Every MD and be like her. She read my medical history before she came to the room so she knew what I went through for the year avoiding what every MD asks you .... what brings you here?
The minute I talked w/her, I already knew she is my doctor who will see me w/my problem. Very thorough, kind, understanding and she explained everything in my level of understanding.
The majority of time was spent with a resident dr. Dr. Wu came in at the end for the final consultation - I would rate her excellent in all categories. I have great confidence in her.
Thank you Dr. Wu - Really nice & explained everything clearly.
Excellent care; Dr. Wu listened and understood my concerns about the medication. I was treated with respect. Excellent doctor and best of all I can TRUST her judgment & advice.
Dr. Wu is a very good, caring, professional. She answers my questions very clear and very helpful. She is a wonderful doctor. I am glad she is my doctor.
She took the time to answer all of my copious notes, and questions.
Dr. Wu is extremely busy did not have enough time to spend with patient.
Dr. Wu is probably one of the very best doctors I have ever seen! She was knowledgeable, caring, kind & excellent!! I was very impressed & feel very fortunate to have been able to have her as my doctor!
The medical staff (MD's) were excellent.
Good.
No options except for one medication were recommended. I asked about an additional measures I could take to address my problem (PT, diet, vitamin supplements) and was told I was already day everything possible. Doctor was not willing to explain other options.
Dr. Wu was wonderful! I couldn't have asked for a better exp.
View More »
Referring Physicians
PHYSICIAN HELPLINE
Phone: 1-866-742-4811
Fax: 650-320-9443
Monday–Friday, 8 a.m.–5 p.m.
Fax: 650-320-9443
Monday–Friday, 8 a.m.–5 p.m.
Stanford Health Care provides comprehensive services to refer and track patients, as well as the latest information and news for physicians and office staff. For help with all referral needs and questions, visit Referral Information.
You may also submit a web referral or complete a referral form and fax it to 650-320-9443 or email the Referral Center at ReferralCenter@stanfordhealthcare.org.
- Send referrals online
- Place radiology and lab orders
- View referral status
- Access medical records